Biotherapeutics & Drug Conjugation  

• Development of site-specific antibody-drug conjugate (ADC), peptide-drug conjugate (PDC), and glycoconjugate vaccine  via selective glycan remodeling, enabling homogeneous drug attachment and optimized pharmacokinetics

• Generation of novel bioconjugates including labeled antibodies, engineered glycoproteins, or functionalized exosomes for targeted delivery or imaging studies.

Cellular and Molecular Biology

• Live cell glycan labeling for imaging, proteomics, and flow cytometry using click chemistry with alkyne-modified probes.

• Mechanistic studies of glycosylation, glycan-protein interactions including Siglecs (Sialic acid-binding Immunoglobulin-like Lectins), and cell-surface glycan mapping.

Antimicrobial Prophylaxis

• Investigational use as a topical agent for reducing pathogenic colonization (e.g., N. gonorrhoeae), with efficacy shown in preclinical mouse models.

Analytical Research

• Exo-enzymatic glycan engineering of exosomes and nanoparticles for functionalization and delivery research.

• Sialoglycan spin labeling for structural biology and electron paramagnetic resonance (EPR) spectroscopy studies.

All applications listed above are intended exclusively for research use only and are not for use in diagnostic procedures.

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